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A Failed Skin Graft

Click on the image to enlarge   Poll Patient Case A patient in her mid-20s sustained full-thickness burns over 80% of her body after sleeping during a house fire, which resulted in a 60% mortality...

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The Latest in Endometrial Cancer: Liquid Profiling, LVSI, and More

Recent research into endometrial cancer has explored minimally invasive versus open surgical approaches, liquid profiling, recurrence prediction, and more. This year, a wealth of research into...

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Revised McDonald Criteria Allows Earlier & More Precise MS Diagnosis

The revised McDonald criteria allow the diagnosis of MS in certain cases in asymptomatic people who have had a radiologically isolated syndrome (RIS). Dissemination in time (DIT) should no longer be...

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Blood Markers Predict MS Progression

Change in serum glial fibrillary acidic protein (sGFAP) during the first 2 years of treatment predicted future risk for progression independent of relapse activity (PIRA) in two independent MS cohorts....

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High Depression Genetic Burden Associated With MS Disease Activity

In a Canadian study, a higher depression genetic burden was associated with increased MS disease activity. The findings exclude reverse causality as a reason for worse outcomes in people with...

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Th1/Th17 CD4+ T Cells Predict Vedolizumab Efficacy in IBD

The following is a summary of “Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+T cells as predictors for response to integrin α4β7-blocking therapy in...

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Efficacy of POS in Healthy Subjects for Reversing Mydriasis

The following is a summary of “Reversal of Pharmacologically Induced Mydriasis with Phentolamine Ophthalmic Solution,” published in the September 2024 issue of Ophthalmology by Pepose et al....

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IL-17 Inhibitors Increase Fungal Infection Risk in Patients With Psoriasis,...

The following is a summary of “Risk of fungal infection in patients with psoriasis receiving biologics: a retrospective single-center cohort study,” published in the September 2024 issue of Dermatology...

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Efficacy of Fazirsiran in AAT Deficiency Liver Disease

The following is a summary of “Fazirsiran for Adults With Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA),” published in the October 2024 issue of...

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Genetic Variation at HERC2 SNP Linked to UM Survival

The following is a summary of “Survival in uveal melanoma patients is linked to genetic variation at HERC2 SNP rs12913832,” published in the September 2024 issue of Ophthalmology by Gelmi et al.  Uveal...

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Comparing Nicardipine and Clevidipine for Hypertensive Crisis Control

The following is a summary of “Evaluation of the Efficacy and Safety of Nicardipine Versus Clevidipine for Blood Pressure Control in Hypertensive Crisis,” published in the October 2024 issue of...

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Long-Lasting Epigenetic Alterations in Neurosyphilis After Treatment

The following is a summary of “Epigenetic Changes in Cerebrospinal Fluid and Blood of People with Neurosyphilis,” published in the October 2024 issue of Infectious Diseases by Mostaghimi et al....

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Phenotypic Analysis of Acute Respiratory Failure Among Patients in ICU with...

The following is a summary of “Derivation and validation of generalized sepsis-induced acute respiratory failure phenotypes among critically ill patients: a retrospective study,” published in the...

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Assessing Itch in Plaque Psoriasis: The Latest Tools & Questionnaires

Dermatologists recently have developed and validated several tools for assessing itch in plaque psoriasis, such as the Peak Pruritus-Numerical Rating Scale. Historically, psoriasis has been considered...

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Brain Mechanisms Supporting Empathy During Pain Perception

The following is a summary of “I feel your pain: higher empathy is associated with higher posterior default mode network activity,” published in the October and 2024 issue of Pain by Oliva et al....

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NTM Pulmonary Disease Incidence & Prevalence Increasing Among Adults 65 Years...

The following is a summary of “Nontuberculous mycobacterial pulmonary disease (NTM PD) incidence trends in the United States, 2010–2019,” published in the October 2024 issue of Infectious Diseases by...

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Focal Inflammation Low After OCR Discontinuation in Patients with RRMS

The following is a summary of “Recurrence of disease activity after ocrelizumab discontinuation in multiple sclerosis,” published in the September 2024 issue of Neurology by Coerver et al....

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Adaptive Humor Skills Reduce Depression and FoP in pwMS

The following is a summary of “Exploring humor as a coping factor against depressive mood and fear of progression in people with multiple sclerosis with moderate disability: A cross-sectional analysis...

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Eculizumab Effectiveness in NMOSD and Risks of Postvaccination Attacks and...

The following is a summary of “Eculizumab Use in Neuromyelitis Optica Spectrum Disorders: Routine Clinical Care Data from a European Cohort,” published in the October 2024 issue of Neurology by...

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Tips for Being an Effective Leader of the Healthcare Team

Linda Girgis, MD, FAAFP, provides expert advice on how to be an effective leader of a healthcare team, and reminds physicians that leading well takes practice. Whether or not we want to be, we are...

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