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Patient Case

A patient with recently diagnosed limited ANCA vasculitis presented with a worsening necrotic skin ulcer. Initially treated with methotrexate for sino-nasal disease, she noticed the lesion, which began “like a pimple,” expanding over two months. A biopsy revealed neutrophilic dermatosis, consistent with pyoderma gangrenosum. Consequently, her treatment was escalated to rituximab, leading to steady improvement over the following months. This case highlights pyoderma gangrenosum as a complication of ANCA vasculitis.

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The post Skin Lesion in ANCA Vasculitis first appeared on Physician's Weekly.