Older patients with T2D who maintain relaxed glycemic control are not at significantly higher risk for hospitalization for most infections, according to a retrospective cohort study published in Diabetes Care. The study involved 103,242 adults aged at least 65 years. Kasia Lipska, MD, and colleagues compared infection-related hospitalization rates over 14 months, stratifying patients into three A1C categories: intensive control (6% to <7%) and two relaxed control levels (7% to <8% and 8% to <9%). The unadjusted risk for hospitalization was significantly higher in patients with A1C 8% to less than 9% (RR, 1.25; 95% CI, 1.13-1.39) compared with those with A1C 6% to less than 7%, but this difference was not significant after adjustment. However, adjusted analysis revealed that patients with A1C 8% to less than 9% had a significantly higher risk for hospitalization for skin, soft tissue, and bone infections (RR, 1.33; 95% CI, 1.05-1.69). The study authors concluded that careful monitoring is necessary for older adults with higher A1C levels.
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